Samenvatting
Corticosteroid hormones are thought to promote optimal behavioral adaptation under fearful conditions primarily via glucocorticoid receptors (GRs) Here we examined - using pharmacological and genetic approaches in mice - if mineralocorticoid receptors (MRs) also play a role in fearful memory formation As expected administration of the GR-antagonist RU38486 prior to training in a fear conditioning paradigm impaired contextual memory when tested 24 (but not when tested 3) h after training Tone-cue memory was enhanced by RU38486 when tested at 4 (but not 25) h after training Interestingly pre (but not post)-training administration of MR antagonist spironolactone impaired contextual memory both at 3 and 24 h after training Similar effects were also found in forebrain-specific MR knockout mice Spironolactone also impaired tone-cue memory but only at 4 h after training These results reveal that in addition to GRs - MRs also play a critical role in establishing fear memories particularly in the early phase of memory formation (C) 2010 Elsevier Inc All rights reserved
Originele taal-2 | English |
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Pagina's (van-tot) | 530-537 |
Aantal pagina's | 8 |
Tijdschrift | Neurobiology of Learning and Memory |
Volume | 94 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Published - nov.-2010 |
Extern gepubliceerd | Ja |