Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice

Ming Zhou*, Eveline H. M. Bakker, Els H. Velzing, Stefan Berger, Melly Oitzl, Marian Joels, Harm J. Krugers

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

64 Citaten (Scopus)


Corticosteroid hormones are thought to promote optimal behavioral adaptation under fearful conditions primarily via glucocorticoid receptors (GRs) Here we examined - using pharmacological and genetic approaches in mice - if mineralocorticoid receptors (MRs) also play a role in fearful memory formation As expected administration of the GR-antagonist RU38486 prior to training in a fear conditioning paradigm impaired contextual memory when tested 24 (but not when tested 3) h after training Tone-cue memory was enhanced by RU38486 when tested at 4 (but not 25) h after training Interestingly pre (but not post)-training administration of MR antagonist spironolactone impaired contextual memory both at 3 and 24 h after training Similar effects were also found in forebrain-specific MR knockout mice Spironolactone also impaired tone-cue memory but only at 4 h after training These results reveal that in addition to GRs - MRs also play a critical role in establishing fear memories particularly in the early phase of memory formation (C) 2010 Elsevier Inc All rights reserved

Originele taal-2English
Pagina's (van-tot)530-537
Aantal pagina's8
TijdschriftNeurobiology of Learning and Memory
Nummer van het tijdschrift4
StatusPublished - nov-2010
Extern gepubliceerdJa

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