Brain-based ranking of cognitive domains to predict schizophrenia

Teresa M. Karrer, Danielle S. Bassett, Birgit Derntl, Oliver Gruber, Andre Aleman, Renaud Jardri, Angela R. Laird, Peter T. Fox, Simon B. Eickhoff, Olivier Grisel, Gael Varoquaux, Bertrand Thirion, Danilo Bzdok*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

9 Citaten (Scopus)
13 Downloads (Pure)


Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions, we developed a data-driven machine-learning strategy and provide a proof of principle in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge on diverse cognitive domains was first condensed into neurotopographical maps. We then examined how the ensuing meta-analytic cognitive priors can distinguish patients and controls using brain morphology and intrinsic functional connectivity. Some affected cognitive domains supported well-studied directions of research on auditory evaluation and social cognition. However, rarely suspected cognitive domains also emerged as disease relevant, including self-oriented processing of bodily sensations in gustation and pain. Such algorithmic charting of the cognitive landscape can be used to make targeted recommendations for future mental health research.

Originele taal-2English
Aantal pagina's21
TijdschriftHuman brain mapping
Nummer van het tijdschrift15
StatusPublished - 15-okt-2019

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