Brain Mineralocorticoid Receptors and Resilience to Stress

Sofia Kanatsou*, Marian Joels, Harm Krugers

*Corresponding author voor dit werk

    OnderzoeksoutputAcademicpeer review

    7 Citaten (Scopus)

    Samenvatting

    Exposure to stressful experiences triggers the release of-among others-glucocorticoids from the adrenal glands. These hormones, cortisol and corticosterone in humans and rodents respectively, activate mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that regulate neuronal activity and behavioral adaptation to stressful experiences. This review discusses molecular properties of MRs, the role of MRs in regulating neuronal function and behavior and, ultimately, evidence that enhanced MR function may confer resilience to stressful experiences.

    Originele taal-2English
    TitelALDOSTERONE
    RedacteurenG Litwack
    UitgeverijAcademic Press
    Hoofdstuk14
    Pagina's341-359
    Aantal pagina's19
    Volume109
    DOI's
    StatusPublished - 2019

    Publicatie series

    NaamVitamins and Hormones
    UitgeverijELSEVIER ACADEMIC PRESS INC
    Volume109
    ISSN van geprinte versie0083-6729

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