Bridging the gap between the randomised clinical trial world and the real world by combination of population-based registry and electronic health record data: A case study in haemato-oncology

R E Kibbelaar, B E Oortgiesen, A M van der Wal-Oost, K Boslooper, J W Coebergh, N J G M Veeger, P Joosten, H Storm, E N van Roon, M Hoogendoorn

Onderzoeksoutputpeer review

28 Citaten (Scopus)
51 Downloads (Pure)


Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented. In this approach, a PBR is combined with an advanced EHR, providing high-quality data for observational studies and support of best practice development. This PBR + EHR approach opens a perspective on randomised registry trials.

Originele taal-2English
Pagina's (van-tot)178-185
Aantal pagina's8
TijdschriftEuropean Journal of Cancer
StatusPublished - nov.-2017

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