Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity

J. Raiko, M. Holstila, K. A. Virtanen, J. Orava, V. Saunavaara, T. Niemi, J. Laine, M. Taittonen, R. J. H. Borra, P. Nuutila, R. Parkkola*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

40 Citaten (Scopus)

Samenvatting

The aim of the present study was to determine whether single-voxel proton magnetic resonance spectroscopy (H-1-MRS) can non-invasively assess triglyceride content in both supraclavicular fat depots and subcutaneous white adipose tissue (WAT) to determine whether these measurements correlate to metabolic variables. A total of 25 healthy volunteers were studied using F-18-fluorodeoxyglucose positron emission tomography (PET) and O-15-H2O PET perfusion during cold exposure, and H-1-MRS at ambient temperature. Image-guided biopsies were collected from nine volunteers. The supraclavicular triglyceride content determined by H-1-MRS varied between 60 and 91% [mean +/- standard deviation (s.d.) 77 +/- 10%]. It correlated positively with body mass index, waist circumference, subcutaneous and visceral fat masses and 8-year diabetes risk based on the Framingham risk score and inversely with HDL cholesterol and insulin sensitivity (M-value; euglycaemic-hyperinsulinaemic clamp). Subcutaneous WAT had a significantly higher triglyceride content, 76-95% (mean +/- s.d. 87 +/- 5%; p = 0.0002). In conclusion, the triglyceride content in supraclavicular fat deposits measured by H-1-MRS may be an independent marker of whole-body insulin sensitivity, independent of brown adipose tissue metabolic activation.

Originele taal-2English
Pagina's (van-tot)516-519
Aantal pagina's4
TijdschriftDiabetes obesity & metabolism
Volume17
Nummer van het tijdschrift5
DOI's
StatusPublished - mei-2015
Extern gepubliceerdJa

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