C3 Epimerization of Glucose, via Regioselective Oxidation and Reduction

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Palladium-catalyzed oxidation can single out the secondary hydroxyl group at C3 in glucose, circumventing the more readily accessible hydroxyl at C6 and the more reactive anomeric hydroxyl. Oxidation followed by reduction results in either allose or allitol, each a rare sugar that is important in biotechnology. Also, N-acetylglucosamine is selectively oxidized at C3. These results demonstrate that glucose and N-acetylglucosamine, the most readily available chiral building blocks, can be versatile substrates in homogeneous catalysis.

Originele taal-2English
Pagina's (van-tot)11439-11443
Aantal pagina's5
TijdschriftJournal of Organic Chemistry
Nummer van het tijdschrift22
StatusPublished - 18-nov.-2016

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