@article{073bd7c69c6c4cc5b0088216d9c2f8c4,
title = "Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor",
abstract = "The (pro) renin-renin receptor, (P) RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P) RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P) RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P) RR was similar to 170-fold higher (P",
keywords = "HUMAN (PRO)RENIN RECEPTOR, TRANSGENIC RATS, RENIN/PRORENIN RECEPTOR, HYPERTROPHY, ACTIVATION, BINDING, CELLS, MICE, GLOMERULOSCLEROSIS, HYPERTENSION",
author = "Hasan Mahmud and Candido, {Wellington Mardoqueu} and {van Genne}, Linda and Inge Vreeswijk-Baudoin and Hongjuan Yu and {van de Sluis}, Bart and {van Deursen}, Jan and {van Gilst}, {Wiek H.} and Sillje, {Herman H. W.} and {de Boer}, {Rudolf A.}",
year = "2014",
month = feb,
day = "25",
doi = "10.1371/journal.pone.0089929",
language = "English",
volume = "9",
journal = "PLOS-One",
issn = "1932-6203",
publisher = "PUBLIC LIBRARY SCIENCE",
number = "2",
}