Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

Hasan Mahmud, Wellington Mardoqueu Candido, Linda van Genne, Inge Vreeswijk-Baudoin, Hongjuan Yu, Bart van de Sluis, Jan van Deursen, Wiek H. van Gilst, Herman H. W. Sillje, Rudolf A. de Boer*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

12 Citaten (Scopus)
309 Downloads (Pure)

Samenvatting

The (pro) renin-renin receptor, (P) RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P) RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P) RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P) RR was similar to 170-fold higher (P

Originele taal-2English
Artikelnummere89929
Aantal pagina's9
TijdschriftPLoS ONE
Volume9
Nummer van het tijdschrift2
DOI's
StatusPublished - 25-feb.-2014

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