Carotid intima media thickness is associated with plasma lipoprotein-associated phospholipase A(2) mass in nondiabetic subjects but not in patients with type 2 diabetes

Alexander Constantinides, L. Joost van Pelt, Jeroen J. J. van Leeuwen, Rindert de Vries, Rene A. Tio, Iwan C. C. van der Horst, Wim J. Sluiter, Robin P. F. Dullaart*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

18 Citaten (Scopus)

Samenvatting

Background A recent meta-analysis showed that both plasma lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity independently predict cardiovascular events. Notably, Lp-PLA(2) activity but not mass was found to be a determinant of cardiovascular outcome in type 2 diabetes mellitus. We questioned whether relationships of carotid intima media thickness (IMT), a measure of subclinical atherosclerosis, with Lp-PLA(2) mass differ between diabetic and nondiabetic subjects.

Materials and methods Relationships of IMT with plasma Lp-PLA(2) mass (turbidimetric immunoassay) were compared in 74 patients with type 2 diabetes and in 64 nondiabetic subjects.

Results IMT was increased (P=0.016), but plasma Lp-PLA(2) mass was decreased in patients with diabetes compared to nondiabetic subjects (277 +/- 66 vs. 327 +/- 62 mu g L-1, P

Conclusions Plasma Lp-PLA(2) may relate to early stages of atherosclerosis development. In diabetes mellitus, in contrast, the association of IMT with plasma Lp-PLA(2) mass is abolished, which could be partly ascribed to redistribution of Lp-PLA(2) mass from apolipoprotein B-containing lipoproteins towards HDL. These findings raise questions about the usefulness of plasma Lp-PLA(2) mass measurement as a marker of subclinical atherosclerosis in type 2 diabetes mellitus.

Originele taal-2English
Pagina's (van-tot)820-827
Aantal pagina's8
TijdschriftEuropean Journal of Clinical Investigation
Volume41
Nummer van het tijdschrift8
DOI's
StatusPublished - aug-2011

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