Cascade Reactions in Multicompartmentalized Polymersomes

Ruud J.R.W. Peters, Maïté Marguet, Sébastien Marais, Marco W. Fraaije, Jan C.M. van Hest, Sébastien Lecommandoux

OnderzoeksoutputAcademicpeer review

432 Citaten (Scopus)
1090 Downloads (Pure)

Samenvatting

Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.
Originele taal-2English
Pagina's (van-tot)146-150
Aantal pagina's5
TijdschriftAngewandte Chemie International Edition
Volume53
Nummer van het tijdschrift1
DOI's
StatusPublished - 2014

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