Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

Valentin Hornillos; Massimo Giannerini; Carlos Vila; Martin Fananas-Mastral; Ben L. Feringa

doi:10.1021/ol402408v

Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

Valentin Hornillos
, Massimo Giannerini
, Carlos Vila
, Martin Fananas-Mastral^*
, Ben L. Feringa

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

67 Citaten (Scopus)

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Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd-2(dba)(3)/XPhos as the catalyst allows for the preparation of biaryl and heterobiagl compounds In high yields under mild conditions (room temperature to 40 degrees C) with short reaction times.

Originele taal-2	English
Pagina's (van-tot)	5114-5117
Aantal pagina's	4
Tijdschrift	Organic letters
Volume	15
Nummer van het tijdschrift	19
DOI's	https://doi.org/10.1021/ol402408v
Status	Published - 4-okt.-2013

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@article{b3c50e8548694b4fa9c03e6f9681d889,

title = "Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides",

abstract = "Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd-2(dba)(3)/XPhos as the catalyst allows for the preparation of biaryl and heterobiagl compounds In high yields under mild conditions (room temperature to 40 degrees C) with short reaction times.",

keywords = "N-HETEROCYCLIC CARBENE, ORTHO-SUBSTITUTED BIARYLS, HIGHLY-ACTIVE CATALYST, CARBON BOND FORMATION, ROOM-TEMPERATURE, SUZUKI-MIYAURA, GENERAL-METHOD, SELECTIVE SYNTHESIS, ARYLBORONIC ACIDS, GRIGNARD-REAGENTS",

author = "Valentin Hornillos and Massimo Giannerini and Carlos Vila and Martin Fananas-Mastral and Feringa, \{Ben L.\}",

year = "2013",

month = oct,

day = "4",

doi = "10.1021/ol402408v",

language = "English",

volume = "15",

pages = "5114--5117",

journal = "Organic letters",

issn = "1523-7060",

publisher = "AMER CHEMICAL SOC INC",

number = "19",

}

TY - JOUR

T1 - Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

AU - Hornillos, Valentin

AU - Giannerini, Massimo

AU - Vila, Carlos

AU - Fananas-Mastral, Martin

AU - Feringa, Ben L.

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd-2(dba)(3)/XPhos as the catalyst allows for the preparation of biaryl and heterobiagl compounds In high yields under mild conditions (room temperature to 40 degrees C) with short reaction times.

AB - Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd-2(dba)(3)/XPhos as the catalyst allows for the preparation of biaryl and heterobiagl compounds In high yields under mild conditions (room temperature to 40 degrees C) with short reaction times.

KW - N-HETEROCYCLIC CARBENE

KW - ORTHO-SUBSTITUTED BIARYLS

KW - HIGHLY-ACTIVE CATALYST

KW - CARBON BOND FORMATION

KW - ROOM-TEMPERATURE

KW - SUZUKI-MIYAURA

KW - GENERAL-METHOD

KW - SELECTIVE SYNTHESIS

KW - ARYLBORONIC ACIDS

KW - GRIGNARD-REAGENTS

U2 - 10.1021/ol402408v

DO - 10.1021/ol402408v

M3 - Article

SN - 1523-7060

VL - 15

SP - 5114

EP - 5117

JO - Organic letters

JF - Organic letters

IS - 19

ER -

Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

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