Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: A preliminary cross-national comparison

Esther Mesman; Boris B. Birmaher; Benjamin I. Goldstein; Tina Goldstein; Eske M. Derks; Marloes Vleeschouwer; Mary Beth Hickey; David Axelson; Kelly Monk; Rasim Diler; Danella Hafeman; Dara J. Sakolsky; Catrien G. Reichart; Marjolein Wals; Frank C. Verhulst; Willem A. Nolen; Manon H. J. Hillegers

doi:10.1016/j.jad.2016.06.011

Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: A preliminary cross-national comparison

Esther Mesman, Boris B. Birmaher, Benjamin I. Goldstein, Tina Goldstein, Eske M. Derks, Marloes Vleeschouwer, Mary Beth Hickey, David Axelson, Kelly Monk, Rasim Diler, Danella Hafeman, Dara J. Sakolsky, Catrien G. Reichart, Marjolein Wals, Frank C. Verhulst, Willem A. Nolen, Manon H. J. Hillegers^*

^*Bijbehorende auteur voor dit werk

Clinical Cognitive Neuropsychiatry Research Program (CCNP)

Onderzoeksoutput › Academic › peer review

31 Citaten (Scopus)

Samenvatting

Objective: Accumulating evidence suggests cross-national differences in adults with bipolar disorder (BD), but also in the susceptibility of their offspring (bipolar offspring). This study aims to explore and clarify cross-national variation in the prevalence of categorical and dimensional psychopathology between bipolar offspringin the US and The Netherlands.

Methods: We compared levels of psychopathology in offspring of the Pittsburgh Bipolar Offspring Study (n=224) and the Dutch Bipolar Offspring Study (n=136) (age 10-18). Categorical psychopathology was ascertained through interviews using the Schedule for Affective Disorders and Schizophrenia for School Age Children (K-SADS-PL), dimensional psychopathology by parental reports using the Child Behavior Checklist (CBCL).

Results: Higher rates of categorical psychopathology were observed in the US versus the Dutch samples (66% versus 44%). We found no differences in the overall prevalence of mood disorders, including BD-I or -II, but more comorbidity in mood disorders in US versus Dutch off spring (80% versus 34%). The strongest predictors of categorical psychopathology were maternal BD (OR: 1.72, p

Limitations: Preliminary measure of inter-site reliability.

Conclusions: We found cross-national differences in prevalence of categorical diagnoses of non-mood disorders in bipolar offspring, but not in mood disorder diagnoses nor in parent-reported dimensional psychopathology. Cross-national variation was only partially explained by between-sample differences. Cultural and methodological explanations for these findings warrant further study. (C) 2016 Elsevier B.V. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	95-102
Aantal pagina's	8
Tijdschrift	Journal of Affective Disorders
Volume	205
DOI's	https://doi.org/10.1016/j.jad.2016.06.011
Status	Published - 15-nov.-2016

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Mesman, E., Birmaher, B. B., Goldstein, B. I., Goldstein, T., Derks, E. M., Vleeschouwer, M., Hickey, M. B., Axelson, D., Monk, K., Diler, R., Hafeman, D., Sakolsky, D. J., Reichart, C. G., Wals, M., Verhulst, F. C., Nolen, W. A., & Hillegers, M. H. J. (2016). Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: A preliminary cross-national comparison. Journal of Affective Disorders, 205, 95-102. https://doi.org/10.1016/j.jad.2016.06.011

@article{6ae379a89c4e4e8b98024ee6c86fe565,

title = "Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: A preliminary cross-national comparison",

abstract = "Objective: Accumulating evidence suggests cross-national differences in adults with bipolar disorder (BD), but also in the susceptibility of their offspring (bipolar offspring). This study aims to explore and clarify cross-national variation in the prevalence of categorical and dimensional psychopathology between bipolar offspringin the US and The Netherlands.Methods: We compared levels of psychopathology in offspring of the Pittsburgh Bipolar Offspring Study (n=224) and the Dutch Bipolar Offspring Study (n=136) (age 10-18). Categorical psychopathology was ascertained through interviews using the Schedule for Affective Disorders and Schizophrenia for School Age Children (K-SADS-PL), dimensional psychopathology by parental reports using the Child Behavior Checklist (CBCL).Results: Higher rates of categorical psychopathology were observed in the US versus the Dutch samples (66% versus 44%). We found no differences in the overall prevalence of mood disorders, including BD-I or -II, but more comorbidity in mood disorders in US versus Dutch off spring (80% versus 34%). The strongest predictors of categorical psychopathology were maternal BD (OR: 1.72, pLimitations: Preliminary measure of inter-site reliability.Conclusions: We found cross-national differences in prevalence of categorical diagnoses of non-mood disorders in bipolar offspring, but not in mood disorder diagnoses nor in parent-reported dimensional psychopathology. Cross-national variation was only partially explained by between-sample differences. Cultural and methodological explanations for these findings warrant further study. (C) 2016 Elsevier B.V. All rights reserved.",

keywords = "Bipolar offspring, High risk, Cross-national, Bipolar disorder, Mood disorder, Child Behavior Checklist, SPECTRUM DISORDERS, MENTAL-HEALTH, UNITED-STATES, CHILDREN, ONSET, ADOLESCENTS, AGE, HISTORY, EPIDEMIOLOGY, ASSOCIATION",

author = "Esther Mesman and Birmaher, {Boris B.} and Goldstein, {Benjamin I.} and Tina Goldstein and Derks, {Eske M.} and Marloes Vleeschouwer and Hickey, {Mary Beth} and David Axelson and Kelly Monk and Rasim Diler and Danella Hafeman and Sakolsky, {Dara J.} and Reichart, {Catrien G.} and Marjolein Wals and Verhulst, {Frank C.} and Nolen, {Willem A.} and Hillegers, {Manon H. J.}",

year = "2016",

month = nov,

day = "15",

doi = "10.1016/j.jad.2016.06.011",

language = "English",

volume = "205",

pages = "95--102",

journal = "Journal of Affective Disorders",

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publisher = "ELSEVIER SCIENCE BV",

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Mesman, E, Birmaher, BB, Goldstein, BI, Goldstein, T, Derks, EM, Vleeschouwer, M, Hickey, MB, Axelson, D, Monk, K, Diler, R, Hafeman, D, Sakolsky, DJ, Reichart, CG, Wals, M, Verhulst, FC, Nolen, WA & Hillegers, MHJ 2016, 'Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: A preliminary cross-national comparison', Journal of Affective Disorders, vol. 205, blz. 95-102. https://doi.org/10.1016/j.jad.2016.06.011

TY - JOUR

T1 - Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder

T2 - A preliminary cross-national comparison

AU - Mesman, Esther

AU - Birmaher, Boris B.

AU - Goldstein, Benjamin I.

AU - Goldstein, Tina

AU - Derks, Eske M.

AU - Vleeschouwer, Marloes

AU - Hickey, Mary Beth

AU - Axelson, David

AU - Monk, Kelly

AU - Diler, Rasim

AU - Hafeman, Danella

AU - Sakolsky, Dara J.

AU - Reichart, Catrien G.

AU - Wals, Marjolein

AU - Verhulst, Frank C.

AU - Nolen, Willem A.

AU - Hillegers, Manon H. J.

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Objective: Accumulating evidence suggests cross-national differences in adults with bipolar disorder (BD), but also in the susceptibility of their offspring (bipolar offspring). This study aims to explore and clarify cross-national variation in the prevalence of categorical and dimensional psychopathology between bipolar offspringin the US and The Netherlands.Methods: We compared levels of psychopathology in offspring of the Pittsburgh Bipolar Offspring Study (n=224) and the Dutch Bipolar Offspring Study (n=136) (age 10-18). Categorical psychopathology was ascertained through interviews using the Schedule for Affective Disorders and Schizophrenia for School Age Children (K-SADS-PL), dimensional psychopathology by parental reports using the Child Behavior Checklist (CBCL).Results: Higher rates of categorical psychopathology were observed in the US versus the Dutch samples (66% versus 44%). We found no differences in the overall prevalence of mood disorders, including BD-I or -II, but more comorbidity in mood disorders in US versus Dutch off spring (80% versus 34%). The strongest predictors of categorical psychopathology were maternal BD (OR: 1.72, pLimitations: Preliminary measure of inter-site reliability.Conclusions: We found cross-national differences in prevalence of categorical diagnoses of non-mood disorders in bipolar offspring, but not in mood disorder diagnoses nor in parent-reported dimensional psychopathology. Cross-national variation was only partially explained by between-sample differences. Cultural and methodological explanations for these findings warrant further study. (C) 2016 Elsevier B.V. All rights reserved.

AB - Objective: Accumulating evidence suggests cross-national differences in adults with bipolar disorder (BD), but also in the susceptibility of their offspring (bipolar offspring). This study aims to explore and clarify cross-national variation in the prevalence of categorical and dimensional psychopathology between bipolar offspringin the US and The Netherlands.Methods: We compared levels of psychopathology in offspring of the Pittsburgh Bipolar Offspring Study (n=224) and the Dutch Bipolar Offspring Study (n=136) (age 10-18). Categorical psychopathology was ascertained through interviews using the Schedule for Affective Disorders and Schizophrenia for School Age Children (K-SADS-PL), dimensional psychopathology by parental reports using the Child Behavior Checklist (CBCL).Results: Higher rates of categorical psychopathology were observed in the US versus the Dutch samples (66% versus 44%). We found no differences in the overall prevalence of mood disorders, including BD-I or -II, but more comorbidity in mood disorders in US versus Dutch off spring (80% versus 34%). The strongest predictors of categorical psychopathology were maternal BD (OR: 1.72, pLimitations: Preliminary measure of inter-site reliability.Conclusions: We found cross-national differences in prevalence of categorical diagnoses of non-mood disorders in bipolar offspring, but not in mood disorder diagnoses nor in parent-reported dimensional psychopathology. Cross-national variation was only partially explained by between-sample differences. Cultural and methodological explanations for these findings warrant further study. (C) 2016 Elsevier B.V. All rights reserved.

KW - Bipolar offspring

KW - High risk

KW - Cross-national

KW - Bipolar disorder

KW - Mood disorder

KW - Child Behavior Checklist

KW - SPECTRUM DISORDERS

KW - MENTAL-HEALTH

KW - UNITED-STATES

KW - CHILDREN

KW - ONSET

KW - ADOLESCENTS

KW - AGE

KW - HISTORY

KW - EPIDEMIOLOGY

KW - ASSOCIATION

U2 - 10.1016/j.jad.2016.06.011

DO - 10.1016/j.jad.2016.06.011

M3 - Article

VL - 205

SP - 95

EP - 102

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -