Cell encapsulation: technical and clinical advances

Gorka Orive, Edorta Santos, Denis Poncelet, Rosa María Hernández, José Luis Pedraz, Lars U Wahlberg, Paul De Vos, Dwaine Emerich

Onderzoeksoutputpeer review

137 Citaten (Scopus)


Treating many chronic diseases will require a tight, minute-to-minute regulation of therapeutic molecules that is currently not achievable with most pharmaceutical therapies. For these diseases, implantable living cellular systems may be able to provide unlimited drug delivery, enabling seamless matching of treatment duration with disease longevity. Cell encapsulation is an advanced technology that achieves this goal and represents a viable therapeutic option. The advanced state of the field has allowed researchers to inch forward into therapeutic domains previously untouchable because of the myriad disparate fields that intersect biomaterials and cells. Here, we discuss the next generation of clinical trials and potential approaches, 'smart' and responsive encapsulation systems, sophisticated and multifunctional devices, and novel imaging tools, together with the future challenges in the field.

Originele taal-2English
Pagina's (van-tot)537-546
Aantal pagina's10
TijdschriftTrends in Pharmacological Sciences
Nummer van het tijdschrift8
StatusPublished - aug.-2015

Citeer dit