Fluorescent nanodiamonds (FNDs) can be used as nanoscale magnetic resonance sensors and stable optical labels. As a first step for using FNDs as nanosensors inside cells, they have to be ingested. Several techniques that improve particle uptake have been used. A simple approach based on commercially available liposomes is used to improve uptake. Uptake into colon cancer cells (HT‐29 cells) is demonstrated. Additionally, it is shown for the first time that one can facilitate diamond uptake into yeast cells by removing the cell wall and creating a so‐called spheroplast. Finally, the characteristics of FNDs coated with lipids and their behavior inside the cells are evaluated.