Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAs

Izabella Slezak-Prochazka; Joost Kluiver; Debora de Jong; Gertrud Kortman; Nancy Halsema; Sibrand Poppema; Bart-Jan Kroesen; Anke van den Berg

doi:10.1371/journal.pone.0076647

Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAs

Izabella Slezak-Prochazka, Joost Kluiver, Debora de Jong, Gertrud Kortman, Nancy Halsema, Sibrand Poppema, Bart-Jan Kroesen, Anke van den Berg^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

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Processing of miRNAs occurs simultaneous with the transcription and splicing of their primary transcripts. For the small subset of exonic miRNAs it is unclear if the unspliced and/or spliced transcripts are used for miRNA biogenesis. We assessed endogenous levels and cellular location of primary transcripts of three exonic miRNAs. The ratio between unspliced and spliced transcripts varied markedly, i.e. >1 for BIC,

Originele taal-2	English
Artikelnummer	e76647
Aantal pagina's	11
Tijdschrift	PLoS ONE
Volume	8
Nummer van het tijdschrift	9
DOI's	https://doi.org/10.1371/journal.pone.0076647
Status	Published - 20-sep-2013

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10.1371/journal.pone.0076647Licentie: CC BY

Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAsFinal publisher's version, 1,19 MBLicentie: CC BY

Citeer dit

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AU - Slezak-Prochazka, Izabella

AU - Kluiver, Joost

AU - de Jong, Debora

AU - Kortman, Gertrud

AU - Halsema, Nancy

AU - Poppema, Sibrand

AU - Kroesen, Bart-Jan

AU - van den Berg, Anke

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AB - Processing of miRNAs occurs simultaneous with the transcription and splicing of their primary transcripts. For the small subset of exonic miRNAs it is unclear if the unspliced and/or spliced transcripts are used for miRNA biogenesis. We assessed endogenous levels and cellular location of primary transcripts of three exonic miRNAs. The ratio between unspliced and spliced transcripts varied markedly, i.e. >1 for BIC,

KW - MICROPROCESSOR COMPLEX

KW - HODGKIN LYMPHOMA

KW - BURKITT-LYMPHOMA

KW - MESSENGER-RNAS

KW - NONCODING RNA

KW - CELLS

KW - EXPRESSION

KW - LINES

KW - SITES

KW - GENE

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