Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAs

Izabella Slezak-Prochazka, Joost Kluiver, Debora de Jong, Gertrud Kortman, Nancy Halsema, Sibrand Poppema, Bart-Jan Kroesen, Anke van den Berg*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

17 Citaten (Scopus)
237 Downloads (Pure)

Samenvatting

Processing of miRNAs occurs simultaneous with the transcription and splicing of their primary transcripts. For the small subset of exonic miRNAs it is unclear if the unspliced and/or spliced transcripts are used for miRNA biogenesis. We assessed endogenous levels and cellular location of primary transcripts of three exonic miRNAs. The ratio between unspliced and spliced transcripts varied markedly, i.e. >1 for BIC,

Originele taal-2English
Artikelnummere76647
Aantal pagina's11
TijdschriftPLoS ONE
Volume8
Nummer van het tijdschrift9
DOI's
StatusPublished - 20-sep-2013

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