Cellular Senescence and the SenescenceAssociated Secretory Phenotype as Drivers of Skin Photoaging

Eleni Fitsiou, Tanya Pulido, Judith Campisi, Fatouma Alimirah, Marco Demaria*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

80 Citaten (Scopus)
208 Downloads (Pure)


Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of age-related phenotypes, and increase the risk for skin cancer-a phenomenon defined as photoaging. In this paper, we review the current knowledge on how UV exposure causes cells to prematurely enter cellular senescence. We describe the mechanisms contributing to the accumulation of senescent cells in the skin and how the persistence of cellular senescence can promote impaired regenerative capacity, chronic inflammation, and tumorigenesis associated with photoaging. We conclude by highlighting the potential of senolytic drugs in delaying the onset and progression of age-associated phenotypes in the skin.

Originele taal-2English
Pagina's (van-tot)1119-1126
Aantal pagina's8
TijdschriftJournal of Investigative Dermatology
Nummer van het tijdschrift4
Vroegere onlinedatum18-dec.-2020
StatusPublished - apr.-2021

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