Central nervous system myeloid cells as drug targets: current status and translational challenges

Knut Biber, Thomas Moeller, Erik Boddeke, Marco Prinz

Onderzoeksoutputpeer review

68 Citaten (Scopus)

Samenvatting

Myeloid cells of the central nervous system (CNS), which include parenchymal microglia, macrophages at CNS interfaces and monocytes recruited from the circulation during disease, are increasingly being recognized as targets for therapeutic intervention in neurological and psychiatric diseases. The origin of these cells in the immune system distinguishes them from ectodermal neurons and other glia and endows them with potential drug targets distinct from classical CNS target groups. However, despite the identification of several promising therapeutic approaches and molecular targets, no agents directly targeting these cells are currently available. Here, we assess strategies for targeting CNS myeloid cells and address key issues associated with their translation into the clinic.

Originele taal-2English
Pagina's (van-tot)110-124
Aantal pagina's15
TijdschriftNature Reviews Drug Discovery
Volume15
Nummer van het tijdschrift2
DOI's
StatusPublished - feb-2016

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