Cerebrospinal fluid β2-microglobulin, monocyte chemotactic protein-1, and soluble tumour necrosis factor α receptors before and after treatment with lamivudine plus zidovudine or stavudine

Roelien H Enting, Norbert A Foudraine, Joep M.A Lange, Suzanne Jurriaans, Tom van der Poll, Gerrit-Jan Weverling, Peter Portegies

OnderzoeksoutputAcademicpeer review

22 Citaten (Scopus)

Samenvatting

CSF levels of beta2-microglobulin (b2m), monocyte chemotactic protein-1 (MCP-1), soluble tumor necrosis factor receptors (sTNFRs), and HIV-1 RNA were determined in 16 neurologically asymptomatic HIV-1 infected patients before and 12 weeks after treatment with lamivudine plus zidovudine or stavudine. b2m levels were significantly higher in patients (1.7 mg/l) compared with controls (0.8 mg/l) (P < 0.001), and decreased to 1.1 mg/l during treatment (P = 0.001). MCP-1 levels were low, and did not change during treatment. Levels of sTNFR type I were elevated in patients (0.92 ng/ml) compared to controls (0.30 ng/ml) (P = 0.03), but did not change during treatment. Levels of sTNFR type II were below the limit of detection in most patients and controls. In conclusion, CSF levels of b2m and HIV-I RNA, but not sTNFRs or MCP-1, are candidate surrogate markers of treatment efficacy in early CNS infection.

Originele taal-2English
Pagina's (van-tot)216-221
Aantal pagina's6
TijdschriftJournal of Neuroimmunology
Volume102
Nummer van het tijdschrift2
DOI's
StatusPublished - 24-jan-2000
Extern gepubliceerdJa

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