Challenges of neuropathic pain: focus on diabetic neuropathy

Daniela C. Rosenberger, Vivian Blechschmidt, Hans Timmerman, Andre Wolff, Rolf-Detlef Treede*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

25 Citaten (Scopus)
38 Downloads (Pure)


Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy. Its complex pathophysiology is not yet fully elucidated, which contributes to underassessment and undertreatment. A mechanism-based treatment of painful diabetic neuropathy is challenging but phenotype-based stratification might be a way to develop individualized therapeutic concepts. Our goal is to review current knowledge of the pathophysiology of peripheral neuropathic pain, particularly painful diabetic neuropathy. We discuss state-of-the-art clinical assessment, validity of diagnostic and screening tools, and recommendations for the management of diabetic neuropathic pain including approaches towards personalized pain management. We also propose a research agenda for translational research including patient stratification for clinical trials and improved preclinical models in relation to current knowledge of underlying mechanisms.

Originele taal-2English
Pagina's (van-tot)589-624
Aantal pagina's36
TijdschriftJournal of Neural Transmission
Nummer van het tijdschrift4
Vroegere onlinedatum8-feb-2020
StatusPublished - apr-2020

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