Changes in thyroid function parameters 3 months after allogeneic and autologous hematopoietic stem cell transplantation in children

Chantal A. Lebbink, Dorine Bresters, Joni P.B. Tersteeg, Cor van den Bos, Miranda P. Dierselhuis, Eef G.W.M. Lentjes, Annemarie A.Verrijn Stuart, Marta Fiocco, Wim J.E. Tissing, Hanneke M. van Santen*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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Background: Thyroid dysfunction (hypo- and hyperthyroidism) has been reported as a late effect after hematopoietic stem cell transplantation (HSCT) in children. Short-term effects of HSCT on thyroid function parameters are, however, unclear. 

Methods: We prospectively evaluated thyroid function parameters before and 3 months after HSCT in all children (<21 years) who underwent HSCT during a 2-year period in the Princess Máxima Center, the Netherlands. 

Results: Among 72 children, none had thyroidal hypothyroidism or hyperthyroidism 3 months after HSCT. Changes in thyroid function parameters (either aberrant thyroid-stimulating hormone [TSH] or free thyroxine [FT4] concentrations) were found in 16% before and in 10% 3 months after HSCT. Reverse triiodothyronine (rT3) was found elevated in 9.3% before and in 37% 3 months after HSCT, which could be related to poor physical condition. An individual decline in FT4 concentration of ≥20% was found in 10.5% (6/57) 3 months after HSCT. 

Conclusion: In conclusion, thyroidal hypo- and hyperthyroidism are very rare 3 months after HSCT. These results indicate that surveillance for hypo- and hyperthyroidism may start later in time. The changes in thyroid function parameters found 3 months after HSCT might reflect euthyroid sick syndrome.

Originele taal-2English
Pagina's (van-tot)503-509
Aantal pagina's7
TijdschriftEuropean Journal of Endocrinology
Nummer van het tijdschrift6
StatusPublished - jun.-2023

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