Channel gating forces govern accuracy of mechano-electrical transduction in hair cells

S. M. van Netten*, T. Dinklo, W. Marcotti, C. J. Kros

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    48 Citaten (Scopus)

    Samenvatting

    Sensory hair cells are known for the exquisite displacement senitivity with which they detect the sound-evoked vibrations in the inner ear. In this article, we determine a stochastically imposed fundamental lower bound on a hair cell's sensitivity to detect mechanically coded information arriving at its hair bundle. Based on measurements of transducer current and its noise in outer hair cells and the application of estimation theory, we show that a hair cell's transducer current carries information that allows the detection of vibrational amplitudes with an accuracy on the order of nanometers. We identify the transducer channel's molecular gating force as the physical factor controlling this accuracy in proportion to the inverse of its magnitude. Further, we show that the match of stochastic channel noise to gating-spring noise implies that the gating apparatus operates at the threshold of negative stiffness.

    Originele taal-2English
    Pagina's (van-tot)15510-15515
    Aantal pagina's6
    TijdschriftProceedings of the National Academy of Sciences of the United States of America
    Volume100
    Nummer van het tijdschrift26
    DOI's
    StatusPublished - 23-dec.-2003

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