Characteristics of patients with false- ST-segment elevation myocardial infarction diagnoses

Hilde E. Groot, Wouter G. Wieringa, Karim D. Mahmoud, Chris P. H. Lexis, Bart Hiemstra, Pim van der Harst, Erik Lipsic*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

3 Citaten (Scopus)


Background: A subgroup of patients presenting with suspected ST-elevation myocardial infarction (STEMI) have no culprit lesion during coronary angiography (false-positive STEMI). Little is known about patient- and system-related factors that are associated with false-positive STEMI. We evaluated the incidence, correlates, delay, final diagnosis, and outcome of patients with false-positive STEMI.

Methods: We studied 827 consecutive patients presenting with suspected STEMI between January 2011-September 2012.

Results: A false positive STEMI activation was identified in 68 patients (8.2%). Patients with false-positive STEMI were younger (57 vs 63 year; p=0.020), less often had hypercholesterolemia (19 vs 43%; p=0.001), and had a higher heart rate (82 vs 75 bpm; p=0.014). The association between these factors and false-positive STEMI activation persisted in multivariate analysis. The duration of symptoms to call was longer in false-positive STEMI patients (128 vs 83 min; p=0.030), although this did not reach statistical significance in multivariate analysis. Final diagnosis in patients with false-positive STEMI activation was particularly from unknown origin (41%). There were no significant differences in mortality at 30 days and one year between patients with STEMI and false-positive STEMI.

Conclusion: The incidence of false-positive STEMI was 8.2% in patients suspected of STEMI. Patients with false-positive STEMI differ from STEMI patients in certain baseline characteristics and in patient delay. Interestingly, absence of coronary disease did not translate into better clinical outcome.

Originele taal-2English
Pagina's (van-tot)339-346
Aantal pagina's8
TijdschriftEuropean Heart Journal: Acute Cardiovascular Care
Nummer van het tijdschrift4
StatusPublished - aug.-2016

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