Characterization of Different Patient Populations with Atrial Fibrillation

Mariëlle Kloosterman

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    Atrial fibrillation (AF) is the most common sustained arrhythmia and its prevalence is rising. The lifetime risk of AF in individuals from European ancestry has increased to ~1 in 3 by age 90 years. This is problematic since AF is associated with increased risk of adverse diseases and events, including among others, heart failure, stroke, myocardial infarction, dementia, and death. Several modifiable and non-modifiable risk factors promote the development and maintenance of AF. AF plagues both women and men, but not in the same manner. Sex differences exist in all facets of the disease: from incidence, risk factors, and clinical presentation, to treatment and outcomes. In this thesis we investigated prevalence of (subclinical) risk factors as well as sex differences in the number of risk factors and AF treatment by using data from several large (intern)national trials.
    The findings of this thesis show that attempting to better characterize patient populations can provide valuable insights. The risks associated with AF are predominately influenced by clinical risk factors. These risk factors, which are present in a unique combination in almost every patient, provide opportunities for patient tailored therapy. Combined with a sex-sensitive approach, that acknowledges and recognizes that differences exist in risk factor profiles and treatment provided to women and men, may allow clinicians to improve the health of the individual patient, as well as the overall patient population. Importantly, risk factor management should start early, and treatments such as catheter ablation, should not be withheld or delayed in women.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    Begeleider(s)/adviseur
    • van Gelder, Isabelle, Supervisor
    • Rienstra, Michiel, Supervisor
    • Maass, Alexander, Co-supervisor
    Datum van toekenning23-nov-2020
    Plaats van publicatie[Groningen]
    Uitgever
    Gedrukte ISBN's978-94-6361-406-1
    DOI's
    StatusPublished - 2020

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