Characterization of G1 and mitotic cyclins of budding yeast

M. Tyers*, I. Fitch, G. Tokiwa, C. Dahmann, R. Nash, M. Linskens, B. Futcher

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

8 Citaten (Scopus)

Samenvatting

It has been known for a decade that in yeast, the CDC28 gene of Saccharomyces cerevisiae and the cdc2+ gene of Schizosaccharomyces pombe are needed at two points in their host's cell cycles: once in G1 phase, for commitment to division, and once again in mitosis (Nurse and Bissett 1981; Piggott et al. 1982). These two genes encode highly homologous proteins, which have proven to be the catalytic subunits of protein kinases (Reed et al. 1985; Simanis and Nurse 1986). The active protein kinase is a complex containing the Cdc28/cdc2 protein and a protein called a cyclin (Draetta et al. 1989). Other subunits may also be present (Brizuela et al. 1987).
Originele taal-2English
Pagina's (van-tot)21-32
Aantal pagina's12
TijdschriftCold spring harbor symposia on quantitative biology
Volume56
DOI's
StatusPublished - 1991
Extern gepubliceerdJa

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