Chemical and biological properties of supramolecular polymer systems based on oligocaprolactones

Patricia Y. W. Dankers, Ellen N. M. van Leeuwen, Gaby M. L. van Gemert, A. J. H. Spiering, Martin C. Harmsen, Linda A. Brouwer, Henk M. Janssen, Anton W. Bosman, Maria J. A. van Luyn, E. W. Meijer*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

83 Citaten (Scopus)

Samenvatting

We show that materials with a diverse range of mechanical and biological properties can be obtained using a modular approach by simply mixing different ratios of oligocaprolactones that are either end-functionalized or chain-extended with quadruple hydrogen bonding ureido-pyrimidinone (UPy) moieties. The use of two UPy-synthons allows for easy synthesis of UPy-modified polymers resulting in high yields. Comparison of end-functionalized UPy-polymers with chain-extended UPy-polymers shows that these polymers behave distinctively different regarding their material and biological properties. The end-modified UPy-polymer is rather stiff and brittle due to its high crystallinity. Disks made of this material fractures after subcutaneous implantation. The material shows a low inflammatory response which is accompanied by the formation of a fibrous capsule, reflecting the inertness of the material. The chain-extended UPy-material on the contrary is practically free of crystalline domains and shows clear flexible properties. This material deforms after in-vivo implantation, accompanied with cellular infiltration. By mixing both polymers, materials with intermediate properties concerning their mechanical and biological behaviour can be obtained. Surprisingly, a 20:80 mixture of both polymers with the chain-extended UPy-polymer in excess shows flexible properties without visible deformation upon implantation for 42 days. This mixture, a blend formed by intimate mixing through UPy-UPy interaction, also shows a mild tissue response accompanied with the formation of a thin capsule. The material does not become more crystalline upon implantation. Hence, this mixture might be an ideal scaffold material for soft tissue engineering due to its flexibility and diminished fibrous tissue formation, and illustrates the strength of the modular approach. (c) 2006 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)5490-5501
Aantal pagina's12
TijdschriftBiomaterials
Volume27
Nummer van het tijdschrift32
DOI's
StatusPublished - nov.-2006

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