Chemoenzymatic and photobiocatalytic strategies for chemical synthesis

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Samenvatting

Broadening the scope of biocatalysis in sustainable chemical synthesis requires the continuous
development of new biocatalytic systems. The work described in this thesis focused on the
development of a series of enzymes to perform crucial catalytic steps in the challenging multistep
synthesis of important precursors to pharmaceutically active compounds. These include allyl
alcohols, N-containing heterocycles and aminopolycarboxylic acids, as well as structurally diverse
amines and azoxy- and azo-aromatics. An important finding is the use of photocatalysts to enable
new catalytic function in flavin-dependent nitroreductases, allowing the selective photoenzymatic
reduction of nitro and keto compounds fueled by (sun)light. Taken together, these developments
illustrate the power of combining different catalysis modes to create new synthetic routes to
bioactive compounds and their precursors.
Originele taal-2English
KwalificatieDoctor of Philosophy
Toekennende instantie
  • Rijksuniversiteit Groningen
Begeleider(s)/adviseur
  • Poelarends, Gerrit, Supervisor
  • Dekker, Frank, Co-supervisor
Datum van toekenning22-jan.-2024
Plaats van publicatie[Groningen]
Uitgever
DOI's
StatusPublished - 2023

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