Chemoenzymatic synthesis of enantiomerically enriched alpha-hydroxyamides

Wiktor Szymanski, Ryszard Ostaszewski*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

11 Citaten (Scopus)

Samenvatting

A study on a chemoenzymatic synthesis of model alpha-hydroxyamide was performed. Special attention was paid to the optimization of the enzymatic process, both on the selection of enzyme and cosolvent. An intriguing influence of cosolvent on the enantioselectivity of Wheat Germ Lipase and Amano PS Lipase catalyzed hydrolysis was observed, as the results obtained proved that enzyme's enantioselectivity is directly correlated with cosolvent's hydrophobicity. In the best example (Wheat Germ lipase, Et2O used as a cosolvent), the reaction proceeded with E = 55, and the target compound was obtained in 33% yield with 92.7%ee. (c) 2007 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)125-128
Aantal pagina's4
TijdschriftJournal of Molecular Catalysis B: Enzymatic
Volume47
Nummer van het tijdschrift3-4
DOI's
StatusPublished - 2-jul-2007

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