Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy

S M M J Castedo; B de Jong; J Wolter Oosterhuis; Vera J S Idenburg; Raquel Seruca; J  Buist; Gerard J te Meerman; Heimen  Schraffordt Koops; Dirk Th Sleijfer

Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy

S M M J Castedo, B de Jong , J Wolter Oosterhuis, Vera J S Idenburg, Raquel Seruca, J Buist , Gerard J te Meerman, Heimen Schraffordt Koops, Dirk Th Sleijfer

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A cytogenetic analysis of 13 mature residual teratomas following chemotherapy revealed modal chromosome numbers ranging from 52 to 85, in agreement with the flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. One tumor, however, lacked that marker.

The comparison between the chromosomal abnormalities found in mature residual teratomas following chemotherapy and those from primary testicular nonseminomas suggests that residual teratomas result from selection of clones from the primary tumor with a less abnormal karyotype

Originele taal-2	English
Pagina's (van-tot)	672-676
Aantal pagina's	5
Tijdschrift	Cancer Research
Volume	49
Nummer van het tijdschrift	3
Status	Published - 1-feb.-1989

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@article{5210447e8833456f9bad1fad69140565,

title = "Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy",

abstract = "A cytogenetic analysis of 13 mature residual teratomas following chemotherapy revealed modal chromosome numbers ranging from 52 to 85, in agreement with the flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. One tumor, however, lacked that marker.The comparison between the chromosomal abnormalities found in mature residual teratomas following chemotherapy and those from primary testicular nonseminomas suggests that residual teratomas result from selection of clones from the primary tumor with a less abnormal karyotype",

author = "Castedo, {S M M J} and {de Jong}, B and Oosterhuis, {J Wolter} and Idenburg, {Vera J S} and Raquel Seruca and J Buist and {te Meerman}, {Gerard J} and {Schraffordt Koops}, Heimen and Sleijfer, {Dirk Th}",

year = "1989",

month = feb,

day = "1",

language = "English",

volume = "49",

pages = "672--676",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "AMER ASSOC CANCER RESEARCH",

number = "3",

}

TY - JOUR

T1 - Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy

AU - Castedo, S M M J

AU - de Jong , B

AU - Oosterhuis, J Wolter

AU - Idenburg, Vera J S

AU - Seruca, Raquel

AU - Buist , J

AU - te Meerman, Gerard J

AU - Schraffordt Koops, Heimen

AU - Sleijfer, Dirk Th

PY - 1989/2/1

Y1 - 1989/2/1

N2 - A cytogenetic analysis of 13 mature residual teratomas following chemotherapy revealed modal chromosome numbers ranging from 52 to 85, in agreement with the flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. One tumor, however, lacked that marker.The comparison between the chromosomal abnormalities found in mature residual teratomas following chemotherapy and those from primary testicular nonseminomas suggests that residual teratomas result from selection of clones from the primary tumor with a less abnormal karyotype

AB - A cytogenetic analysis of 13 mature residual teratomas following chemotherapy revealed modal chromosome numbers ranging from 52 to 85, in agreement with the flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. One tumor, however, lacked that marker.The comparison between the chromosomal abnormalities found in mature residual teratomas following chemotherapy and those from primary testicular nonseminomas suggests that residual teratomas result from selection of clones from the primary tumor with a less abnormal karyotype

M3 - Article

SN - 0008-5472

VL - 49

SP - 672

EP - 676

JO - Cancer Research

JF - Cancer Research

IS - 3

ER -

Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy

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