Chronic kidney disease: Insights from social and genetic epidemiology


    873 Downloads (Pure)


    Chronic kidney disease is a major global health burden, caused by the complex interplay between environmental and genetic factors. The results in this thesis provide valuable insights into these causes. First, I corroborate the existence of socioeconomic disparities in kidney disease, as those with lower education seem to have higher rates of chronic kidney disease and faster rates of kidney function decline. Second, those with a positive family history have a threefold higher risk of having chronic kidney disease, and there is strong evidence for a genetic component to kidney function and kidney damage. Third, genetic risk of chronic kidney disease may be offset by higher socioeconomic status. Finally, educational level may not be the main driver of socioeconomic disparities in chronic kidney disease, as the genetic evidence for a causal effect of educational level is inconclusive.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    • Snieder, Harold, Supervisor
    • Gansevoort, Ron, Supervisor
    • Bultmann, Ute, Supervisor
    Datum van toekenning7-okt.-2020
    Plaats van publicatie[Groningen]
    Gedrukte ISBN's978-94-034-2609-9
    Elektronische ISBN's978-94-034-2608-2
    StatusPublished - 2020

    Citeer dit