Chronic kidney disease: Insights from social and genetic epidemiology

C. H. L. Thio

doi:10.33612/diss.133648108

Chronic kidney disease: Insights from social and genetic epidemiology

C. H. L. Thio

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Chronic kidney disease is a major global health burden, caused by the complex interplay between environmental and genetic factors. The results in this thesis provide valuable insights into these causes. First, I corroborate the existence of socioeconomic disparities in kidney disease, as those with lower education seem to have higher rates of chronic kidney disease and faster rates of kidney function decline. Second, those with a positive family history have a threefold higher risk of having chronic kidney disease, and there is strong evidence for a genetic component to kidney function and kidney damage. Third, genetic risk of chronic kidney disease may be offset by higher socioeconomic status. Finally, educational level may not be the main driver of socioeconomic disparities in chronic kidney disease, as the genetic evidence for a causal effect of educational level is inconclusive.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Snieder, Harold, Supervisor Gansevoort, Ron, Supervisor Bultmann, Ute, Supervisor
Datum van toekenning	7-okt.-2020
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	978-94-034-2609-9
Elektronische ISBN's	978-94-034-2608-2
DOI's	https://doi.org/10.33612/diss.133648108
Status	Published - 2020

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10.33612/diss.133648108

Title and contentsFinal publisher's version, 185 KB
Chapter 1Final publisher's version, 229 KB
Chapter 2Final publisher's version, 190 KB
Chapter 3Final publisher's version, 376 KB
Chapter 4Final publisher's version, 830 KB
Chapter 5Final publisher's version, 212 KB
Chapter 6Final publisher's version, 394 KB
Chapter 7Final publisher's version, 288 KB
Chapter 8Final publisher's version, 300 KB
Chapter 9Final publisher's version, 292 KB
Chapter 10Final publisher's version, 270 KB
Complete thesisFinal publisher's version, 2,35 MB
PropositionsFinal publisher's version, 45,9 KB

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abstract = "Chronic kidney disease is a major global health burden, caused by the complex interplay between environmental and genetic factors. The results in this thesis provide valuable insights into these causes. First, I corroborate the existence of socioeconomic disparities in kidney disease, as those with lower education seem to have higher rates of chronic kidney disease and faster rates of kidney function decline. Second, those with a positive family history have a threefold higher risk of having chronic kidney disease, and there is strong evidence for a genetic component to kidney function and kidney damage. Third, genetic risk of chronic kidney disease may be offset by higher socioeconomic status. Finally, educational level may not be the main driver of socioeconomic disparities in chronic kidney disease, as the genetic evidence for a causal effect of educational level is inconclusive.",

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AB - Chronic kidney disease is a major global health burden, caused by the complex interplay between environmental and genetic factors. The results in this thesis provide valuable insights into these causes. First, I corroborate the existence of socioeconomic disparities in kidney disease, as those with lower education seem to have higher rates of chronic kidney disease and faster rates of kidney function decline. Second, those with a positive family history have a threefold higher risk of having chronic kidney disease, and there is strong evidence for a genetic component to kidney function and kidney damage. Third, genetic risk of chronic kidney disease may be offset by higher socioeconomic status. Finally, educational level may not be the main driver of socioeconomic disparities in chronic kidney disease, as the genetic evidence for a causal effect of educational level is inconclusive.

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