Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study

Ilse G Pranger, Eva Corpeleijn, Frits A J Muskiet, Ido P Kema, Cécile Singh-Povel, Stephan J L Bakker

OnderzoeksoutputAcademicpeer review

20 Citaten (Scopus)
42 Downloads (Pure)

Samenvatting

BACKGROUND: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio.

METHODS: Data were obtained from Lifelines (n = 769). Dairy fat intake was determined by FFQ. Fatty acids were measured in fasting plasma triglycerides (TG), phospholipids (PL) and cholesterol esters (CE).

RESULTS: Median(25th-75th percentile) intakes of dairy and dairy fat were 322(209-447) and 12.3(8.4-17.4) g/d respectively. A pilot study showed that trans-C18:1(n-7) and CLA were only detectable in TG and PL. Of the established markers, TG C15:0 was most strongly associated with dairy fat intake (standardized β (std.β)=0.286, R2 = 0.111). Of the less established markers, TG trans-C18:1(n-7) was most strongly associated with dairy fat intake (Std.β = 0.292, R2 = 0.115), followed by PL CLA (Std.β = 0.272, R2 = 0.103) and PL trans-C18:1(n-7) (Std.β = 0.269, R2 = 0.099). In TG, a combination of C15:0 and trans-C18:1(n-7) performed best (R2 = 0.128). In PL, a combination of C14:0, C15:0, trans-C18:1(n-7) and CLA performed best (R2 = 0.143).

CONCLUSION: Trans-C18:1(n-7) and CLA can be used as biomarkers of dairy fat intake. Additionally, combining established with less established markers allowed even stronger predictions for dairy fat intake.

Originele taal-2English
Pagina's (van-tot)360-372
Aantal pagina's13
TijdschriftBiomarkers
Volume24
Nummer van het tijdschrift4
DOI's
StatusPublished - 28-mei-2019

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