Circulating microRNAs in patients with acute heart failure

Adriaan Alexander Voors (Uitvinder), Ekaterina Sergeevna Ovchinnikova (Uitvinder), Eugene Berezikov (Uitvinder), Peter van der Meer (Uitvinder)

Onderzoeksoutput

Samenvatting

The invention relates to diagnosis, prognosis or classification of acute heart failure (AHF) using circulating micro RNAs as molecular markers. Provided is a method of determining whether a subject has AHF, is at increased risk of developing AHF, or has AHF that is progressing, comprising measuring in a test sample obtained from the subject at least four mi RNAs selected from the group consisting of mi R-18a-5p, mi R-26b-5p, mi R-27a-3p, mi R-30e-5p, mi R-106a-5p, mi R-199a-3p, and mi R-652-3p. Also provided is a diagnostic kit comprising a plurality of primers and/or probes specific for determining expression levels at least four of mi R-18a-5p, mi R- 26b-5p, mi R-27a-3p, mi R-30e-5p, mi R-106a-5p, mi R-199a-3p, and mi R-652- 3p.
Originele taal-2English
OctrooinummerWO2016133395
Prioriteitsdatum20/02/2015
StatusPublished - 25-aug.-2016

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