Clinical and economic impact of non-adherence in COPD: A systematic review

Job F. M. van Boven*, Niels H. Chavannes, Thys van der Molen, Maureen P. M. H. Rutten-van Molken, Maarten J. Postma, Stefan Vegter

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

163 Citaten (Scopus)
175 Downloads (Pure)


BACKGROUND: Medication for Chronic Obstructive Pulmonary Disease (COPD) has shown to substantially reduce symptoms and slow progression of disease. However, non-adherence to medication is common and associated with worsened clinical and economic outcomes.

OBJECTIVE: The objective of this study was to perform a systematic review of published literature to assess the impact of non-adherence to COPD medication on clinical and economic outcomes.

METHODS: A search in PubMed and Web of Science databases was conducted of original studies published from database inception to 2012. Studies must report on the association between adherence to COPD medication and outcomes, published in English in peer-reviewed journals and full texts needed to be available.

RESULTS: Twelve full articles were included in the review. Most studies were retrospective database studies. Seven studies reported on the association between adherence and clinical outcomes, two on mortality, three on costs, four on quality of life and one on work productivity. Results indicated a clear association between adherence and both clinical and economic outcomes. Evidence from studies revealed increased hospitalizations, mortality, quality of life and loss of productivity among non-adherent patients.

CONCLUSION: This review revealed a clear association between non-adherence to COPD medication and worsened clinical and economic outcomes making non-adherent patients a priority for cost-effective interventions.

Originele taal-2English
Pagina's (van-tot)103-113
Aantal pagina's11
TijdschriftRespiratory Medicine
Nummer van het tijdschrift1
StatusPublished - jan.-2014

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