Clinical and genetic aspects of idiopathic epilepsies in childhood

PMC Callenbach, AMJM van den Maagdenbergb, RR Frants, OF Brouwer*

*Bijbehorende auteur voor dit werk

    Onderzoeksoutput: Review articlepeer review

    15 Citaten (Scopus)

    Samenvatting

    The identification of the first genes associated with idiopathic epilepsy has been an important breakthrough in the field of epilepsy research. In almost all cases these genes were found to encode components of voltage- or ligand-gated ion channels or functionally related structures. For many other idiopathic syndromes, there is linkage evidence to one or more chromosomes, but the genes have not yet been identified. Identification of the responsible genes and their gene products will further increase the knowledge of the pathogenic mechanisms involved in epilepsy, and will hopefully facilitate the development of drug targets for the effective treatment of epilepsy.

    This review gives an overview of the clinical characteristics and an update of genetic research of those idiopathic childhood epilepsies for which genes have been identified and the monogenic idiopathic childhood epilepsies for which mapping data are available. © 2005 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

    Originele taal-2English
    Pagina's (van-tot)91-103
    Aantal pagina's13
    TijdschriftEuropean Journal of Paediatric Neurology
    Volume9
    Nummer van het tijdschrift2
    DOI's
    StatusPublished - 2005

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