In this thesis, clinical and radiographic data from the GLAS cohort were analyzed. The key findings were: 1) small reduction in spinal radiographic progression during long-term treatment with TNF-α inhibitors, 2) frequent involvement of cervical facet joints, 3) relatively high prevalence and incidence of radiographic vertebral fractures, 4) identification of risk factors (e.g. smoking and obesity) for high disease activity and poor disease outcome, 5) gender differences in patient-reported outcome measures, and 6) a new, disease-specific questionnaire to assess daily physical activity in axial SpA.
|Kwalificatie||Doctor of Philosophy|
|Datum van toekenning||8-mrt-2017|
|Plaats van publicatie||[Groningen]|
|Status||Published - 2017|
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, H. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006