Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

Robin E. A. Tjon Pian Gi, Michel R. M. San Giorgi, Lorian Slagter-Menkema, Bettien M. van Hemel, Bernard F. A. M. van der Laan, Edwin R. van den Heuvel, Frederik G. Dikkers*, Ed M. D. Schuuring

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

38 Citaten (Scopus)


Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.

Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.

Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (

Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.

Originele taal-2English
Pagina's (van-tot)1625-1632
Aantal pagina's8
TijdschriftHead and Neck: Journal of the Sciences and Specialties of the Head and Neck
Nummer van het tijdschrift11
StatusPublished - nov-2015

Citeer dit