Clinical efficacy of agomelatine in depression: the evidence

JA Den Boer*, FJ Bosker, Y Meesters

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    53 Citaten (Scopus)

    Samenvatting

    Despite the advances of recent decades, there is still an urgent need for antidepressants with improved efficacy, safety and tolerability. Agomelatine is a new antidepressant with an innovative pharmacological profile. It is the first melatonergic antidepressant, and is a potent agonist of melatonin receptors (MT1 and MT2) with 5-HT2c antagonist properties. The efficacy of 25 mg/day agomelatine in treating major depressive disorder (MDD) has been demonstrated in a number of placebo-controlled studies. Evidence of improvement in depressive symptoms was observed in a dose-ranging study in which 25 mg/day agomelatine was significantly better than placebo, whatever the rating scale used (Hamilton Rating Scale for Depression, Clinical Global Impression, and Montgomery-Asberg Depression Rating Scale). These results have been confirmed in two similarly designed placebo-controlled studies. Agomelatine also produces a significant improvement in anxiety compared to placebo, according to Hamilton Rating Scale for Anxiety scores. The efficacy of agomelatine has been studied in subpopulations with more severe depression, demonstrating its efficacy in these difficult-to-treat patients. In view of the available data on agomelatine, this antidepressant can be regarded as an innovative treatment for MDD patients, offering a new approach in the management of depressed patients.

    Originele taal-2English
    Pagina's (van-tot)S21-S24
    Aantal pagina's4
    TijdschriftINTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
    Volume21
    StatusPublished - feb.-2006
    EvenementSatellite Symposium on Acting on Melatonergic Receptors held at the 18th ECNP Congress - , Netherlands
    Duur: 22-okt.-200526-okt.-2005

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