Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins

FW Asselbergs*, P van der Harst, GAJ Jessurun, RA Tio, WH van Gilst

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

37 Citaten (Scopus)


Impaired endothelial function is recognised as one of the earliest events of atherogenesis. Endothelium-dependent vasomotion has been the principal method to assess endothelial function. In this article, we will discuss the clinical value of the different techniques to evaluate endothelium-dependent vasomotion. To date, there seems not to be a simple and reliably endothelial function test to identify asymptomatic subjects at increased risk for cardiovascular disease in clinical practice. Recent studies indicate that pharmacological interventions, in particular with ACE-inhibitors and statins, might improve endothelial function. However, there is no solid evidence that improvement of endothelial function is a necessity for the observed reduction in cardiovascular events by these compounds. Overall, at this moment, there is no place in clinical practice for the use of endothelial function as a method for risk assessment or target of pharmacological interventions. (c) 2005 Elsevier Inc. All rights reserved.

Originele taal-2English
Pagina's (van-tot)125-140
Aantal pagina's16
TijdschriftVascular pharmacology
Nummer van het tijdschrift3
StatusPublished - feb-2005

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