Clomiphene citrate utilization in the Netherlands 1998-2007

H. Wang*, J.A. Land, H.J. Bos, M.K. Bakker, L.T.W. de Jong-van den Berg

*Bijbehorende auteur voor dit werk


3 Citaten (Scopus)


BACKGROUND: Infertility is a growing problem in western societies. Few studies have examined the drug utilization of common treatments for infertility. Clomiphene citrate (CC) is the first-line treatment for normogonadotropic women with absent or irregular ovulation. We examined CC use among women at reproductive age in the northern Netherlands.

METHODS: Drug dispensing data of CC between 1998 and 2007 were retrieved from the database. Two-year prevalences of CC use per 1000 women covered by the database were calculated and stratified by 5-year age group. The duration of CC use was analyzed using Kaplan-Meier survival analysis.

RESULTS: From the database, a total of 1854 women aged 20-44 years initiated ovulation induction treatment with CC only in the northern Netherlands during 1998 and 2007. The 2-year prevalence of CC use increased from 6.66 per 1000 women during 1998-1999 to 7.24 per 1000 during 2002-2003, followed by a decrease to 4.82 per 1000 in 2006-2007 (P <0.05). Median duration of CC use was four cycles for women,30 years of age, three cycles for women aged 30-39 and two cycles for women aged above 40.

CONCLUSIONS: There is no increase of CC use during 1998-2007, and indeed a decrease of CC use during recent years, among women at reproductive age in northern Netherlands.

Originele taal-2English
Pagina's (van-tot)1227-1231
Aantal pagina's5
TijdschriftHuman Reproduction
Nummer van het tijdschrift5
StatusPublished - mei-2011

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