Coenzyme A: to make it or uptake it?

Ody C. M. Sibon; Erick Strauss

doi:10.1038/nrm.2016.110

Coenzyme A: to make it or uptake it?

Ody C. M. Sibon, Erick Strauss^*

^*Corresponding author voor dit werk

Biology-Related, Artificial, and Interventional Neuroscience (BRAIN)

Onderzoeksoutput: Editorial › Academic › peer review

52 Citaten (Scopus)

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The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.

Originele taal-2	English
Pagina's (van-tot)	605-606
Aantal pagina's	2
Tijdschrift	Nature Reviews Molecular Cell Biology
Volume	17
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1038/nrm.2016.110
Status	Published - okt.-2016

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title = "Coenzyme A: to make it or uptake it?",

abstract = "The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.",

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AU - Strauss, Erick

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N2 - The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.

AB - The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.

KW - ESCHERICHIA-COLI

KW - TRANSPORTER

KW - 4-PHOSPHOPANTETHEINE

KW - METABOLISM

U2 - 10.1038/nrm.2016.110

DO - 10.1038/nrm.2016.110

M3 - Editorial

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EP - 606

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

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Coenzyme A: to make it or uptake it?

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