Collagen type VI interaction improves human islet survival in immunoisolating microcapsules for treatment of diabetes

L. Alberto Llacua*, Arjan Hoek, Bart J. de Haan, Paul de Vos

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

18 Citaten (Scopus)
295 Downloads (Pure)

Samenvatting

Collagens are the most abundant fibrous protein in the human body and constitute the main structural element of the extracellular matrix. It provides mechanical and physiological support for cells. In the pancreas, collagen VI content is more than double that of collagen I or IV. It is a major component of the islet-exocrine interface and could be involved in islet-cell survival. To test the impact of collagen VI on human encapsulated pancreatic islets-cells, we tested the effects of exogenous collagen type VI on in vitro functional survival of alginate encapsulated human islet-cells. Concentrations tested ranged from 0.1 to 50 mu g/ml. Islets in capsules without collagen type VI served as control. Islet-cell interaction with collagen type VI at concentrations of 0.1 and 10 mu g/ml, promoted islet-cell viability (p

Originele taal-2English
Artikelnummere1420449
Pagina's (van-tot)60-68
Aantal pagina's9
TijdschriftIslets
Volume10
Nummer van het tijdschrift2
DOI's
StatusPublished - 2018

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