Colonic delivery of plymyxin E and four quinolones for flora suppression

Joris Jan Maria van Saene


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The high doses of antimicrobials to be taken orally are frequently associated with side-effects including headache, sickness, nausea and/or vomiting, stomachache, abdominal pain, gastro-intestinal disturbances and diarrhoea. Moreover, a systemic antibiotic concentration following absorption is theoretically not required for these two goals. The high frequency of these side-effects often leads to a poor compliance, at least in the conscious patient. The major aim of this study is the development of an oral administration form that is followed by an identical (or even better or more efficient) microbial and endotoxin suppression associated with a substantial reduction or absence of side-effects.... Zie: Summary
Originele taal-2English
KwalificatieDoctor of Philosophy
  • Lerk, Coenraad, Supervisor
Gedrukte ISBN's9090036911
StatusPublished - 1990

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