Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

M. W. M. D. Lutgens; B. Oldenburg; P. D. Siersema; A. A. van Bodegraven; G. Dijkstra; D. W. Hommes; D. J. de Jong; P. C. F. Stokkers; C. J. van der Woude; F. P. Vleggaar; ICC

doi:10.1038/sj.bjc.6605359

Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

M. W. M. D. Lutgens, B. Oldenburg, P. D. Siersema, A. A. van Bodegraven, G. Dijkstra, D. W. Hommes, D. J. de Jong, P. C. F. Stokkers, C. J. van der Woude, F. P. Vleggaar^*, ICC

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

118 Citaten (Scopus)

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BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.

METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.

RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).

CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.

British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.com

Originele taal-2	English
Pagina's (van-tot)	1671-1675
Aantal pagina's	5
Tijdschrift	British Jounal of Cancer
Volume	101
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1038/sj.bjc.6605359
Status	Published - 10-nov.-2009

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10.1038/sj.bjc.6605359Licentie: CC BY-NC-SA

Colonoscopic surveillance improves survivalFinal publisher's version, 248 KBLicentie: CC BY-NC-SA

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Parel Infammatory Bowel Disease (IBD)
Dijkstra, G. (Creator), F.M., T. (Other), Lowenberg, M. (Creator), Bosma, C. (Data Manager) & Terpstra, F. (Data Manager), University of Groningen, 2017
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Lutgens, M. W. M. D., Oldenburg, B., Siersema, P. D., van Bodegraven, A. A., Dijkstra, G., Hommes, D. W., de Jong, D. J., Stokkers, P. C. F., van der Woude, C. J., Vleggaar, F. P., & ICC (2009). Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease. British Jounal of Cancer, 101(10), 1671-1675. https://doi.org/10.1038/sj.bjc.6605359

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title = "Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease",

abstract = "BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.comPublished online 13 October 2009 (C) 2009 Cancer Research UK",

keywords = "inflammatory bowel disease, colorectal cancer, surveillance, survival, tumour stage, IBD, CRC, ULCERATIVE-COLITIS, CROHNS COLITIS, POPULATION, METAANALYSIS, NETHERLANDS, GUIDELINES, CARCINOMA, MORTALITY, PROGRAM, COHORT",

author = "Lutgens, {M. W. M. D.} and B. Oldenburg and Siersema, {P. D.} and {van Bodegraven}, {A. A.} and G. Dijkstra and Hommes, {D. W.} and {de Jong}, {D. J.} and Stokkers, {P. C. F.} and {van der Woude}, {C. J.} and Vleggaar, {F. P.} and ICC",

year = "2009",

month = nov,

day = "10",

doi = "10.1038/sj.bjc.6605359",

language = "English",

volume = "101",

pages = "1671--1675",

journal = "British Jounal of Cancer",

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T1 - Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

AU - Lutgens, M. W. M. D.

AU - Oldenburg, B.

AU - Siersema, P. D.

AU - van Bodegraven, A. A.

AU - Dijkstra, G.

AU - Hommes, D. W.

AU - de Jong, D. J.

AU - Stokkers, P. C. F.

AU - van der Woude, C. J.

AU - Vleggaar, F. P.

AU - ICC

PY - 2009/11/10

Y1 - 2009/11/10

N2 - BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.comPublished online 13 October 2009 (C) 2009 Cancer Research UK

AB - BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.comPublished online 13 October 2009 (C) 2009 Cancer Research UK

KW - inflammatory bowel disease

KW - colorectal cancer

KW - surveillance

KW - survival

KW - tumour stage

KW - IBD

KW - CRC

KW - ULCERATIVE-COLITIS

KW - CROHNS COLITIS

KW - POPULATION

KW - METAANALYSIS

KW - NETHERLANDS

KW - GUIDELINES

KW - CARCINOMA

KW - MORTALITY

KW - PROGRAM

KW - COHORT

U2 - 10.1038/sj.bjc.6605359

DO - 10.1038/sj.bjc.6605359

M3 - Article

C2 - 19826420

VL - 101

SP - 1671

EP - 1675

JO - British Jounal of Cancer

JF - British Jounal of Cancer

SN - 0007-0920

IS - 10

ER -

Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

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