Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

Naomi R. Wray*, Cisca Wijmenga, Patrick F. Sullivan, Jian Yang, Peter M. Visscher

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

127 Citaten (Scopus)

Samenvatting

The evidence that most adult-onset common diseases have a polygenic genetic architecture fully consistent with robust biological systems supported by multiple back-up mechanisms is now overwhelming. In this context, we consider the recent "omnigenic'' or "core genes'' model. A key assumption of the model is that there is a relatively small number of core genes relevant to any disease. While intuitively appealing, this model may underestimate the biological complexity of common disease, and therefore, the goal to discover core genes should not guide experimental design. We consider other implications of polygenicity, concluding that a focus on patient stratification is needed to achieve the goals of precision medicine.

Originele taal-2English
Pagina's (van-tot)1573-1580
Aantal pagina's8
TijdschriftCell
Volume173
Nummer van het tijdschrift7
DOI's
StatusPublished - 14-jun-2018

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