Compaction properties of isomalt

Gerad K. Bolhuis*, Jeffrey J. P. Engelhart, Anko C. Eissens

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

27 Citaten (Scopus)

Samenvatting

Although other polyols have been described extensively as filler-binders in direct compaction of tablets, the polyol isomalt is rather unknown as pharmaceutical excipient, in spite of its description in all the main pharmacopoeias. In this paper the compaction properties of different types of ispomalt were studied. The types used were the standard product sieved isomalt, milled isomalt and two types of agglomerated isomalt with a different ratio between 6-O-alpha-D-glucopyranosyl-D-sorbitol (GPS) and 1-O-alpha-D-glucopyranosyl-D-mannitol dihydrate (GPM). Powder flow properties, specific Surface area and densities of the different types were investigated. Compactibility was investigated by compression of the tablets on a compaction Simulator, simulating the compression oil high-speed tabletting machines. Lubricant sensitivity was measured by compressing unlubricated tablets and tablets lubricated with 1% magnesium stearate oil all instrumented hydraulic press. Sieved isomair had excellent flow properties but the compactibility was found to be poor whereas the lubricant sensitivity was high. Milling resulted in both a strong increase in compactibility as an effect of the higher surface area for bonding and a decrease in lubricant sensitivity as an effect of the higher Surface area to be coated with magnesium stearate. However, the flow properties of milled isomalt were too bad for use as filler-binder in direct compaction. just as could be expected, agglomeration of milled isomalt by fluid bed agglomeration improved flowability. The good compaction properties and the low lubricant sensitivity were maintained. This effect is Caused by all early fragmentation of the agglomerated material during the compaction process, producing clean, lubricant-free particles and a high Surface for bonding. The different GPS/GPM ratios of the agglomerated isomalt types Studied had no significant effect oil the compaction properties. (C) 2009 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)621-625
Aantal pagina's5
TijdschriftEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume72
Nummer van het tijdschrift3
DOI's
StatusPublished - aug-2009

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