Comparing the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on renal function decline in diabetes

Yunyu Huang*, Flora M. Haaijer-Ruskamp, Jaco Voorham

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    3 Citaten (Scopus)

    Samenvatting

    Aim: To compare effectiveness of angiotensin-converting enzyme inhibitors (ACEis)/angiotensin receptor blockers (ARBs) for protecting Type 2 diabetes mellitus (DM2) patients from renal function decline in a real-world setting. Methods: Retrospective cohort study of new ACEi/ARB users in 2007-2012 in an unselected primary care DM2 population. Outcome is decline in renal function stage (combining estimated glomerular filtration rate and albuminuria). Patients were matched on a propensity score. Extended Cox models with time-varying covariates were used to estimate hazard ratios of outcome. Results: The time to renal function decline for ARB users was slightly, but not significantly longer than for ACEi users (hazard ratio: 0.80; 95% CI: 0.58-1.10; p = 0.166). Conclusion: This study did not show significant differences between the classes in preventing renal function decline in DM2 patients in primary care.

    Originele taal-2English
    Pagina's (van-tot)229-237
    Aantal pagina's9
    TijdschriftJournal of Comparative Effectiveness Research
    Volume5
    Nummer van het tijdschrift3
    DOI's
    StatusPublished - mei-2016

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