Samenvatting
Buruli ulcer is infectious neglected tropical disease caused by Mycobacterium ulcerans. Usually
patients report to the hospital at an advanced stage of the disease resulting in prolonged hospital
admission, eventually, severe functional limitations and heavy and socio-economic burden. The
mode of transmission is still unknown. Early case detection associated with specific antimicrobial
treatment is the main strategy to control this disease.
This thesis aims to study the prevention of Buruli ulcer. It especially focuses on the efficacy of
community health volunteers in the early case detection, the rational use of nonspecific antibiotics
for prophylaxis after surgery or in case of suspected secondary infection, the paradoxical reaction
and the functional limitations after specific antibiotic treatment in patients affected by Buruli
ulcer.
Our findings will impact the direction of future control activities in Buruli ulcer disease.
Strengths and limitations of the studies contained in this thesis as well as direction for future
research are presented. To conclude, it appears that of all strategies currently explored and
discussed here, an optimized strategy for early case detection has the highest priority since it
will reduce the
• duration of treatment,
• secondary infection,
• paradoxical reaction,
• permanent functional limitation,
• direct and indirect financial burden and,
• overall suffering caused by this diseases.
patients report to the hospital at an advanced stage of the disease resulting in prolonged hospital
admission, eventually, severe functional limitations and heavy and socio-economic burden. The
mode of transmission is still unknown. Early case detection associated with specific antimicrobial
treatment is the main strategy to control this disease.
This thesis aims to study the prevention of Buruli ulcer. It especially focuses on the efficacy of
community health volunteers in the early case detection, the rational use of nonspecific antibiotics
for prophylaxis after surgery or in case of suspected secondary infection, the paradoxical reaction
and the functional limitations after specific antibiotic treatment in patients affected by Buruli
ulcer.
Our findings will impact the direction of future control activities in Buruli ulcer disease.
Strengths and limitations of the studies contained in this thesis as well as direction for future
research are presented. To conclude, it appears that of all strategies currently explored and
discussed here, an optimized strategy for early case detection has the highest priority since it
will reduce the
• duration of treatment,
• secondary infection,
• paradoxical reaction,
• permanent functional limitation,
• direct and indirect financial burden and,
• overall suffering caused by this diseases.
| Originele taal-2 | English |
|---|---|
| Kwalificatie | Doctor of Philosophy |
| Toekennende instantie |
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| Begeleider(s)/adviseur |
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| Datum van toekenning | 8-feb.-2016 |
| Plaats van publicatie | [Groningen] |
| Uitgever | |
| Gedrukte ISBN's | 978-90-367-8554-9 |
| Elektronische ISBN's | 978-90-367-8555-6 |
| Status | Published - 2016 |