TY - PAT
T1 - Compounds for treatment of alzheimer’s disease
AU - Henning, Robert Henk
AU - Van der Graaf, Adrianus Cornelis
AU - Krenning, Guido
AU - Swart, Daniel
AU - de Veij Mestdagh, Christina Francoise
AU - Vogelaar, Pieter Cornelis
PY - 2021/6/17
Y1 - 2021/6/17
N2 - The invention relates to certain chromanol, quinone or hydroquinone compounds and ‘ derivatives thereof for treatment of Alzheimer’s disease and/or for improving memory , function. Specifically, the present invention relates to chromanol compounds chosen from (6— \ 5 hydroxy-2,5,7,8—tetramethylchroman—Zyl)(piperazin-l -yl)methanone, ((S)-6-hydroxy-2,5,7,8~ tetramethyl—N—((R)-piperidin—3—yl)chroman—2—carboxamide hydrochloride and S-(6—hydroxy— 2,5 ,7, 8~tetramethylchroman—2-yl)(4-(2—hydroxyethyl)piperazin- 1 -y1)methanone, and pharmaceutically acceptable salts thereof.
AB - The invention relates to certain chromanol, quinone or hydroquinone compounds and ‘ derivatives thereof for treatment of Alzheimer’s disease and/or for improving memory , function. Specifically, the present invention relates to chromanol compounds chosen from (6— \ 5 hydroxy-2,5,7,8—tetramethylchroman—Zyl)(piperazin-l -yl)methanone, ((S)-6-hydroxy-2,5,7,8~ tetramethyl—N—((R)-piperidin—3—yl)chroman—2—carboxamide hydrochloride and S-(6—hydroxy— 2,5 ,7, 8~tetramethylchroman—2-yl)(4-(2—hydroxyethyl)piperazin- 1 -y1)methanone, and pharmaceutically acceptable salts thereof.
M3 - Patent
M1 - WO2021118359
Y2 - 2020/12/11
ER -