Computational approaches for RNA structure ensemble deconvolution from structure probing data

Sharon Aviran*, Danny Incarnato*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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RNA structure probing experiments have emerged over the last decade as a straightforward way to determine the structure of RNA molecules in a number of different contexts. Although powerful, the ability of RNA to dynamically interconvert between, and to simultaneously populate, alternative structural configurations, poses a nontrivial challenge to the interpretation of data derived from these experiments. Recent efforts aimed at developing computational methods for the reconstruction of coexisting alternative RNA conformations from structure probing data are paving the way to the study of RNA structure ensembles, even in the context of living cells. In this review, we critically discuss these methods, their limitations and possible future improvements.

Originele taal-2English
Aantal pagina's23
TijdschriftJournal of Molecular Biology
StatusE-pub ahead of print - 17-mei-2022

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