Computational approaches for RNA structure ensemble deconvolution from structure probing data

Sharon Aviran*, Danny Incarnato*

*Corresponding author voor dit werk

Onderzoeksoutput: Review articlepeer review

23 Citaten (Scopus)
294 Downloads (Pure)

Samenvatting

RNA structure probing experiments have emerged over the last decade as a straightforward way to determine the structure of RNA molecules in a number of different contexts. Although powerful, the ability of RNA to dynamically interconvert between, and to simultaneously populate, alternative structural configurations, poses a nontrivial challenge to the interpretation of data derived from these experiments. Recent efforts aimed at developing computational methods for the reconstruction of coexisting alternative RNA conformations from structure probing data are paving the way to the study of RNA structure ensembles, even in the context of living cells. In this review, we critically discuss these methods, their limitations and possible future improvements.

Originele taal-2English
Artikelnummer167635
Aantal pagina's23
TijdschriftJournal of Molecular Biology
Volume434
Nummer van het tijdschrift18
Vroegere onlinedatum17-mei-2022
DOI's
StatusPublished - 30-sep.-2022

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