Computational Modeling of Realistic Cell Membranes

Siewert J. Marrink, Valentina Corradi, Paulo C. T. Souza, Helgi I. Ingólfsson, D. Peter Tieleman, Mark S. P. Sansom

OnderzoeksoutputAcademicpeer review

148 Citaten (Scopus)
255 Downloads (Pure)

Samenvatting

Cell membranes contain a large variety of lipid types and are crowded with proteins, endowing them with the plasticity needed to fulfill their key roles in cell functioning. The compositional complexity of cellular membranes gives rise to a heterogeneous lateral organization, which is still poorly understood. Computational models, in particular molecular dynamics simulations and related techniques, have provided important insight into the organizational principles of cell membranes over the past decades. Now, we are witnessing a transition from simulations of simpler membrane models to multicomponent systems, culminating in realistic models of an increasing variety of cell types and organelles. Here, we review the state of the art in the field of realistic membrane simulations and discuss the current limitations and challenges ahead.

Originele taal-2English
Pagina's (van-tot)6184-6226
Aantal pagina's43
TijdschriftChemical reviews
Volume119
Nummer van het tijdschrift9
Vroegere onlinedatum9-jan-2019
DOI's
StatusPublished - 8-mei-2019

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