Computational modeling of the human serum proteome response to colon resection surgery

Cheng-Jian Xu, Huub C. J. Hoefsloot*, Martijn Dijkstra, Klaas Havenga, Han Roelofsen, Roel J. Vonk, Age K. Smilde

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)


Principal component analysis (PCA) is much used in exploring tithe-course biological data sets, but does not distinguish variation between time and subjects. This study proposes a new integrated approach by combining analysis of variance (ANOVA) and three component modeling methods. The former was used to separate the between- and within-subject variation, and the latter represent modeling strategies on a scale moving from commonality to individuality. The proposed approach was applied to a surface-enhanced laser desorption and ionization time of flight mass spectrometry (SELDI-TOF-MS) data set of a serum protein expression time course before and after colon resection. Two common biological processes are identified and individual differences among patients were also detected, and the biological relevance of both is discussed. (C) 2009 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)20-27
Aantal pagina's8
TijdschriftAnalytica Chimica Acta
Nummer van het tijdschrift1
StatusPublished - 19-feb-2010

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