Computational modelling for dry-powder inhalers

Ralf Kröger, Robert Woolhouse, Michael Becker, Herbert Wachtel, Anne de Boer, Marc Horner

OnderzoeksoutputAcademicpeer review

Samenvatting

Computational fluid dynamics (CFD) is a simulation tool used for modelling powder flow through inhalers to allow optimisation both of device design and drug powder. Here, Ralf Kröger, Consulting Senior CFD Engineer, ANSYS Germany GmbH; Marc Horner, Lead Technical Services Engineer, Healthcare, ANSYS, Inc; Robert Woolhouse, Senior CFD Engineer, ANSYS UK, Ltd; Michael Becker, PhD Student, and Herbert Wachtel, Senior Principal Scientist, both of Boehringer Ingelheim Pharma GmbH & Co KG; and Anne De Boer, Research Leader Inhalation, University of Groningen, Groningen, The Netherlands, describe in detail how CFD was used in the optimisation of the TwincerTM dry-powder inhaler, extensions of current particle modelling physics to account for particle-particle interactions, and the benefits of this approach in product development. © 2012 Frederick Furness Publishing.
Originele taal-2English
Pagina's (van-tot)30-33
Aantal pagina's4
TijdschriftONdrugDelivery
Nummer van het tijdschriftAPRIL
StatusPublished - 1-apr.-2012

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